Across TCGA cell cohorts, TOP1MT RNA expression is significantly associated with the go_rna of many other GO terms, with 4,557 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TOP1MT-associated GO terms across cancer lineages are DNA topological change, Ribosome assembly, and IMP biosynthetic process. Each is linked with TOP1MT in more than 14 cancer types. Because this analysis shows association rather than direction, both TOP1MT-to-partner and partner-to-TOP1MT results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP1MT→partner) and Y-score (partner→TOP1MT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA topological change →	+0.158	+1.608	.001	<.001	3	15
BONE	Ribosome assembly →	+0.087	+1.353	.001	<.001	3	13
URINARY_TRACT	IMP biosynthetic process →	+0.257	+1.559	<.001	<.001	3	12
BONE	Host-mediated activation of viral transcription →	+0.154	+1.540	<.001	.001	3	12
LUNG_NSCLC_LUSC	Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.147	+0.975	<.001	.003	3	11
BONE	Cellular response to salt →	+0.135	+1.297	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,557 associations by consensus.

Exploration

TOP1MT survival (RNA) · tumor vs normal (RNA) · all TOP1MT data types