Across TCGA cell cohorts, TOP1MT mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TOP1MT-associated genes across cancer lineages are HHLA1, LRRC52, and PRSS48. Each is linked with TOP1MT in more than 1 cancer types. Because this analysis shows association rather than direction, both TOP1MT-to-partner and partner-to-TOP1MT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP1MT→partner) and Y-score (partner→TOP1MT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	HHLA1 →	+0.006	+4.807	<.001	.006	3	1
BREAST	LRRC52 →	+0.062	+4.232	<.001	.002	3	1
BREAST	PRSS48 →	+0.084	+4.064	<.001	.003	3	1
BREAST	KCNK16 →	+0.023	+3.672	.001	.006	3	1
STOMACH	GH2 →	+0.076	+4.247	<.001	<.001	3	1
CNS	GIMAP7 →	+0.044	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

TOP1MT survival (RNA) · tumor vs normal (RNA) · all TOP1MT data types