Across TCGA cell cohorts, TOP1MT mutation is significantly associated with the mutation status of many other genes, with 3,070 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TOP1MT-associated genes across cancer lineages are FNIP2, PTPRN, and MOCOS. Each is linked with TOP1MT in more than 3 cancer types. Because this analysis shows association rather than direction, both TOP1MT-to-partner and partner-to-TOP1MT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP1MT→partner) and Y-score (partner→TOP1MT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FNIP2 →	+4.584	+3.942	.002	.002	1	4
BLOOD_Leukemia	PTPRN →	+3.050	+3.247	.008	.008	1	4
BLOOD_Leukemia	MOCOS →	+3.313	+3.430	.005	.005	1	4
CNS	OR5K3 →	+5.614	+5.044	.003	.003	1	3
STOMACH	ZBTB10 →	+4.584	+3.942	.002	.002	1	3
BREAST	FREM2 →	+3.510	+3.807	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,070 associations by consensus.

Exploration

TOP1MT survival (RNA) · tumor vs normal (RNA) · all TOP1MT data types