TOMM40L

Across TCGA pan-cancer cohorts, TOMM40L mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TOMM40L data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TOMM40L mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TOMM40L expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, GBM, and LSCC are the cancer types where TOMM40L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.326	1.000	.038	3	view →
GBM	OS	Tertile	All	0.346	0.543	.043	2	view →
LSCC	DFS	Quartile	All	0.594	1.000	.049	1	view →
CCRCC	DFS	Tertile	II,III,IV	1.000	0.765	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TOMM40L–LUAD (DFS)

Open the LUAD breakdown →