TOMM22

Across TCGA patient cohorts, TOMM22 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TOMM22-associated genes across cancer lineages are RNU6-921P, RNA5SP411, and RNA5SP410. Each is linked with TOMM22 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOMM22-to-partner and partner-to-TOMM22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-921P grouped by TOMM22-low versus TOMM22-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOMM22→partner) and Y-score (partner→TOMM22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNU6-921P →	+0.529	+6.902	<.001	<.001	3	2
UCEC	RNA5SP411 →	+1.779	+3.393	<.001	.007	3	2
UCEC	RNA5SP410 →	+1.148	+3.789	<.001	.002	3	2
COAD	RNU6-591P →	+0.373	+7.741	<.001	.009	3	2
LIHC	RNU7-12P →	+0.757	+5.447	<.001	.005	3	1
UCEC	MIR6075 →	+0.657	+4.638	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

RNU6-921P by TOMM22 expression — LIHC

Explore this box plot interactively →