TOMM22

Across TCGA pan-cancer cohorts, TOMM22 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TOMM22’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where TOMM22 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TOMM22 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LIHC, HNSC, and KIRC are the cancer types where TOMM22 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOMM22 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.087	<.001	9	view →
HNSC	Male	IV	+0.755	<.001	8	view →
KIRC	All	All	+0.199	<.001	8	view →
LUSC	Female	All	+1.030	<.001	6	view →
BRCA	All	All	+0.211	<.001	6	view →
CHOL	Male	All	+2.081	<.001	5	view →
LUAD	Female	All	+0.462	<.001	5	view →
STAD	All	II,III,IV	+0.513	<.001	4	view →
COAD	Female	II,III,IV	+0.460	.003	4	view →
BLCA	All	All	+0.395	.018	3	view →
THCA	All	All	−0.184	.008	2	view →
ESCA	All	All	+0.736	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TOMM22–LIHC

Open the LIHC breakdown →