TOM1L2

Across TCGA patient cohorts, TOM1L2 mutation is significantly associated with the RNA expression of many other genes, with 2,151 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOM1L2-associated genes across cancer lineages are LSM6P2, RPS27P22, and TRDV1. Each is linked with TOM1L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOM1L2-to-partner and partner-to-TOM1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LSM6P2 grouped by TOM1L2-low versus TOM1L2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOM1L2→partner) and Y-score (partner→TOM1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LSM6P2 →	+0.355	+4.017	<.001	.004	3	2
CESC	RPS27P22 →	+0.239	+4.816	<.001	.003	3	2
UCEC	TRDV1 →	+0.590	+1.992	<.001	<.001	3	2
UCEC	SMARCA5-AS1 →	+0.224	+4.124	<.001	<.001	3	2
UCEC	YTHDF3-AS1 →	+0.602	+1.992	<.001	<.001	3	1
UCEC	IGHV3OR16-8 →	+0.523	+2.284	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,151 associations by consensus.

LSM6P2 by TOM1L2 expression — BLCA

Explore this box plot interactively →