TOM1L2

Across TCGA pan-cancer cohorts, TOM1L2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TOM1L2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TOM1L2 RNA is repressed in tumor relative to normal tissue. In most cancer types TOM1L2 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and KIRC are the cancer types where TOM1L2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOM1L2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.664	<.001	11	view →
BLCA	All	All	−0.875	<.001	11	view →
KIRC	Male	II,III,IV	−1.070	<.001	10	view →
COAD	Female	II,III,IV	−0.980	<.001	10	view →
THCA	All	III,IV	−0.896	<.001	10	view →
LUAD	Male	II,III,IV	−1.563	<.001	9	view →
LIHC	Female	II,III,IV	+1.325	<.001	9	view →
KIRP	Male	All	−1.115	<.001	9	view →
LUSC	All	II,III,IV	−1.030	<.001	8	view →
UCEC	All	III,IV	−1.553	<.001	6	view →
BRCA	All	III,IV	−0.595	<.001	6	view →
CHOL	Female	All	+2.160	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TOM1L2–KICH

Open the KICH breakdown →