TOM1L2

Across TCGA cell cohorts, TOM1L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,741 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TOM1L2-associated GO terms across cancer lineages are Negative regulation of organelle assembly, Retrograde transport, endosome to Golgi, and Vacuole organization. Each is linked with TOM1L2 in more than 16 cancer types. Because this analysis shows association rather than direction, both TOM1L2-to-partner and partner-to-TOM1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of organelle assembly grouped by TOM1L2-low versus TOM1L2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOM1L2→partner) and Y-score (partner→TOM1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of organelle assembly →	+0.115	+1.698	.006	.001	3	17
STOMACH	Retrograde transport, endosome to Golgi →	+0.093	+1.654	.001	.006	3	17
OESOPHAGUS	Vacuole organization →	+0.054	+1.608	<.001	<.001	3	16
STOMACH	Positive regulation of autophagy →	+0.077	+1.808	<.001	<.001	3	16
STOMACH	Process utilizing autophagic mechanism →	+0.106	+1.932	<.001	<.001	2	16
STOMACH	Autophagy →	+0.106	+1.932	<.001	<.001	2	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,741 associations by consensus.

Negative regulation of organelle assembly by TOM1L2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →