TOM1L1

Across TCGA cell cohorts, TOM1L1 mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOM1L1-associated genes across cancer lineages are GCAT, CBY1, and FAM149A. Each is linked with TOM1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOM1L1-to-partner and partner-to-TOM1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by TOM1L1-low versus TOM1L1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOM1L1→partner) and Y-score (partner→TOM1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.277	+3.212	.002	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.592	+3.299	.003	.004	3	1
LARGE_INTESTINE	FAM149A →	+1.109	+3.067	.008	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.192	<.001	.002	3	1
LARGE_INTESTINE	QRSL1 →	+0.656	+3.212	<.001	.006	3	1
LARGE_INTESTINE	TRMT10A →	+0.766	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

GCAT by TOM1L1 expression — LARGE_INTESTINE

Explore this box plot interactively →