TOM1

Across TCGA patient cohorts, TOM1 mutation is significantly associated with the RNA expression of many other genes, with 1,165 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOM1-associated genes across cancer lineages are RNU6-81P, RNU6-796P, and RNU6-687P. Each is linked with TOM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOM1-to-partner and partner-to-TOM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-81P grouped by TOM1-low versus TOM1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOM1→partner) and Y-score (partner→TOM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU6-81P →	+0.254	+4.567	.008	.008	3	2
STAD	RNU6-796P →	+0.932	+4.290	<.001	.008	3	2
STAD	RNU6-687P →	+0.402	+4.798	<.001	.006	3	2
STAD	RNA5SP49 →	+0.718	+4.401	<.001	.006	3	2
LUAD	ARL5AP1 →	+0.204	+5.087	<.001	.004	3	2
COAD	MIR4418 →	+1.044	+4.893	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,165 associations by consensus.

RNU6-81P by TOM1 expression — STAD

Explore this box plot interactively →