TOM1

Across TCGA patient cohorts, TOM1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOM1-associated genes across cancer lineages are MSH6, Notch1, and ERK2. Each is linked with TOM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOM1-to-partner and partner-to-TOM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by TOM1-low versus TOM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOM1→partner) and Y-score (partner→TOM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.503	-2.999	.001	.035	3	2
UCEC	Notch1 →	+0.153	+2.820	.024	.035	3	2
UCEC	ERK2 →	+0.261	+2.459	.005	.020	3	1
UCEC	PI3K-p85 →	+0.254	+2.179	.012	.034	3	1
UCEC	Src_pY416 →	-0.256	-2.446	.028	.020	3	1
UCEC	Syk →	+0.448	+2.472	.013	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MSH6 by TOM1 expression — UCEC

Explore this box plot interactively →