TOM1

Across TCGA cell cohorts, TOM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,928 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TOM1-associated GO terms across cancer lineages are Regulation of endosome organization, Macroautophagy, and Regulation of vacuole organization. Each is linked with TOM1 in more than 17 cancer types. Because this analysis shows association rather than direction, both TOM1-to-partner and partner-to-TOM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of endosome organization grouped by TOM1-low versus TOM1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOM1→partner) and Y-score (partner→TOM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of endosome organization →	+0.295	+1.738	<.001	<.001	3	18
STOMACH	Macroautophagy →	+0.079	+1.101	.001	<.001	2	18
LUNG_NSCLC_LUSC	Regulation of vacuole organization →	+0.076	+0.942	.001	.002	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of autophagy →	+0.113	+1.443	<.001	<.001	3	16
KIDNEY	Cytosolic transport →	+0.080	+1.005	<.001	.002	3	16
BONE	COPI-coated vesicle budding →	+0.152	+1.116	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,928 associations by consensus.

Regulation of endosome organization by TOM1 expression — OESOPHAGUS

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