TOLLIP

Across TCGA pan-cancer cohorts, TOLLIP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TOLLIP data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TOLLIP mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TOLLIP expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where TOLLIP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.824	0.578	.008	39	view →
PDAC	OS	Tertile	All	0.665	0.427	.002	9	view →
CCRCC	OS	Tertile	All	0.939	0.535	.013	9	view →
GBM	OS	Tertile	All	0.194	0.504	.022	4	view →
LUAD	DFS	Tertile	III,IV	0.412	0.968	.031	4	view →
LSCC	DFS	Tertile	All	0.518	0.916	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TOLLIP–HNSC (OS)

Open the HNSC breakdown →