TOLLIP

Across TCGA patient cohorts, TOLLIP mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOLLIP-associated genes across cancer lineages are mTOR_pS2448, Rad50, and Src_pY527. Each is linked with TOLLIP in more than 1 cancer types. Because this analysis shows association rather than direction, both TOLLIP-to-partner and partner-to-TOLLIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TOLLIP-low versus TOLLIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOLLIP→partner) and Y-score (partner→TOLLIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.175	-3.680	.002	.001	3	2
UCEC	Rad50 →	-0.203	-1.584	.032	.036	3	2
UCEC	Src_pY527 →	-0.356	-2.449	.035	.019	3	2
UCEC	EGFR_pY1068 →	-0.257	-3.169	.009	<.001	3	1
UCEC	ACC_pS79 →	+0.269	+1.884	.048	.030	3	1
UCEC	INPP4B →	-0.277	-2.321	.029	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

mTOR_pS2448 by TOLLIP expression — UCEC

Explore this box plot interactively →