TOLLIP

Across TCGA cell cohorts, TOLLIP RNA expression is significantly associated with the RNA expression of many other genes, with 11,296 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TOLLIP-associated genes across cancer lineages are PNPLA2, TSSC4, and SIRT3. Each is linked with TOLLIP in more than 19 cancer types. Because this analysis shows association rather than direction, both TOLLIP-to-partner and partner-to-TOLLIP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TOLLIP versus PNPLA2 in URINARY_TRACT, with a Pearson correlation of 0.66.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOLLIP→partner) and Y-score (partner→TOLLIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PNPLA2 →	+2.144	+1.010	<.001	<.001	3	19
STOMACH	TSSC4 →	+1.016	+1.119	<.001	<.001	2	20
STOMACH	SIRT3 →	+1.026	+1.027	<.001	.001	3	18
UPPER_AERODIGESTIVE_TRACT	TAF10 →	+1.090	+1.167	<.001	<.001	3	18
SOFT_TISSUE	PHRF1 →	+1.030	+1.039	<.001	<.001	3	18
BREAST	RNH1 →	+1.148	+1.177	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,296 associations by consensus.

TOLLIP vs PNPLA2 — URINARY_TRACT

Explore this scatter interactively →