TOLLIP

Across TCGA cell cohorts, TOLLIP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,700 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TOLLIP-associated GO terms across cancer lineages are Macroautophagy, Endocytic recycling, and Retrograde transport, endosome to Golgi. Each is linked with TOLLIP in more than 16 cancer types. Because this analysis shows association rather than direction, both TOLLIP-to-partner and partner-to-TOLLIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macroautophagy grouped by TOLLIP-low versus TOLLIP-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOLLIP→partner) and Y-score (partner→TOLLIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Macroautophagy →	+0.085	+1.223	<.001	<.001	3	17
STOMACH	Endocytic recycling →	+0.063	+1.119	<.001	<.001	3	16
STOMACH	Retrograde transport, endosome to Golgi →	+0.089	+1.108	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of autophagy →	+0.069	+1.118	<.001	<.001	3	15
STOMACH	Endosomal transport →	+0.071	+1.118	.001	<.001	3	15
STOMACH	Cytosolic transport →	+0.077	+1.012	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,700 associations by consensus.

Macroautophagy by TOLLIP expression — STOMACH

Explore this box plot interactively →