TOE1

Across TCGA pan-cancer cohorts, TOE1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TOE1 data layer compared with 20 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TOE1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TOE1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, UCEC, and PRAD are the cancer types where TOE1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.054	0.881	<.001	48	view →
UCEC	DFS	Median	II,III,IV	1.000	0.440	.021	24	view →
PRAD	DFS	Median	All	0.085	0.774	.007	6	view →
ESCA	OS	Median	II,III,IV	0.277	0.686	.033	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TOE1–KIRC (OS)

Open the KIRC breakdown →