Across TCGA patient cohorts, TOB2 mutation is significantly associated with the RNA expression of many other genes, with 1,916 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOB2-associated genes across cancer lineages are RN7SL248P, SIGLEC27P, and PHKG1P1. Each is linked with TOB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOB2-to-partner and partner-to-TOB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOB2→partner) and Y-score (partner→TOB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.060	+3.219	<.001	.004	3	2
COAD	SIGLEC27P →	+0.085	+5.392	<.001	.002	3	2
CESC	PHKG1P1 →	+0.034	+4.144	<.001	.009	3	2
CESC	CYCSP22 →	+0.078	+4.569	<.001	.005	3	2
UCEC	NFYBP1 →	+0.153	+2.127	.004	.001	3	2
BLCA	RNU6-660P →	+0.288	+5.018	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,916 associations by consensus.

Exploration

TOB2 survival (RNA) · tumor vs normal (RNA) · all TOB2 data types