TOB1

Across TCGA cell cohorts, TOB1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOB1-associated genes across cancer lineages are KRTAP10-3, TEX43, and KRTAP12-3. Each is linked with TOB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOB1-to-partner and partner-to-TOB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-3 grouped by TOB1-low versus TOB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOB1→partner) and Y-score (partner→TOB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRTAP10-3 →	+0.029	+2.657	.006	.007	3	2
BLOOD_Leukemia	TEX43 →	+0.141	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.124	+5.539	<.001	.003	3	1
LARGE_INTESTINE	C14orf180 →	+0.142	+3.477	<.001	.001	3	1
LARGE_INTESTINE	MDS2 →	+0.359	+3.626	<.001	.001	3	1
LARGE_INTESTINE	MYMX →	+0.371	+2.841	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

KRTAP10-3 by TOB1 expression — LARGE_INTESTINE

Explore this box plot interactively →