TNS3

Across TCGA patient cohorts, TNS3 mutation is significantly associated with the RNA expression of many other genes, with 7,082 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNS3-associated genes across cancer lineages are FXYD6, RNA5SP247, and ZC3H14. Each is linked with TNS3 in more than 4 cancer types. Because this analysis shows association rather than direction, both TNS3-to-partner and partner-to-TNS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FXYD6 grouped by TNS3-low versus TNS3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNS3→partner) and Y-score (partner→TNS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FXYD6 →	-0.859	-3.422	.008	.005	3	5
LIHC	RNA5SP247 →	+0.292	+3.054	.003	.004	3	4
UCEC	ZC3H14 →	+0.252	+1.306	.002	<.001	3	4
UCEC	VRK1 →	+0.415	+1.436	.001	<.001	3	4
STAD	PAPLN →	-1.212	-3.700	<.001	.001	3	4
UCEC	SRP54 →	+0.467	+1.884	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,082 associations by consensus.

FXYD6 by TNS3 expression — STAD

Explore this box plot interactively →