TNS3

Across TCGA pan-cancer cohorts, TNS3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TNS3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TNS3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNS3 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, THCA, and STAD are the cancer types where TNS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.695	<.001	11	view →
THCA	Male	III,IV	−2.172	<.001	10	view →
STAD	Male	III,IV	+1.735	<.001	8	view →
LUAD	Female	All	−1.101	<.001	8	view →
LIHC	Female	II,III,IV	+0.949	<.001	7	view →
LUSC	Female	II,III,IV	−2.141	<.001	6	view →
KICH	All	All	−0.624	.001	3	view →
KIRP	All	All	−0.554	<.001	3	view →
CHOL	All	All	+1.203	.001	2	view →
COAD	Male	II,III,IV	+0.438	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TNS3–HNSC

Open the HNSC breakdown →