TNS3

Across TCGA cell cohorts, TNS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,420 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TNS3-associated GO terms across cancer lineages are Positive regulation of cell-substrate junction organization, Epiboly, and Regulation of cell-substrate adhesion. Each is linked with TNS3 in more than 13 cancer types. Because this analysis shows association rather than direction, both TNS3-to-partner and partner-to-TNS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell-substrate junction organization grouped by TNS3-low versus TNS3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNS3→partner) and Y-score (partner→TNS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of cell-substrate junction organization →	+0.211	+2.873	<.001	<.001	3	14
SKIN	Epiboly →	+0.144	+1.380	<.001	.006	3	13
BONE	Regulation of cell-substrate adhesion →	+0.128	+2.702	<.001	<.001	3	13
BONE	Interleukin-10-mediated signaling pathway →	+0.257	+2.515	.001	.006	3	13
BONE	Regulation of cell-substrate junction organization →	+0.146	+2.320	<.001	<.001	3	12
BONE	Protein targeting to lysosome involved in chaperone-mediated autophagy →	+0.183	+2.164	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,420 associations by consensus.

Positive regulation of cell-substrate junction organization by TNS3 expression — BONE

Explore this box plot interactively →