TNS3

Across TCGA cell cohorts, TNS3 mutation is significantly associated with the RNA expression of many other genes, with 294 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNS3-associated genes across cancer lineages are MTRNR2L6, OR10Q1, and AGBL3. Each is linked with TNS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNS3-to-partner and partner-to-TNS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L6 grouped by TNS3-low versus TNS3-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNS3→partner) and Y-score (partner→TNS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.130	+4.357	<.001	.006	3	3
URINARY_TRACT	OR10Q1 →	+0.027	+4.087	<.001	.009	3	2
SKIN	AGBL3 →	+0.474	+2.502	.003	.005	3	2
SKIN	C6orf136 →	+0.571	+2.502	<.001	.005	3	2
OVARY	SOX1 →	+0.786	+4.187	<.001	.002	3	2
OVARY	NLRP2B →	+0.048	+4.392	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 294 associations by consensus.

MTRNR2L6 by TNS3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →