TNS2

Across TCGA patient cohorts, TNS2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNS2-associated genes across cancer lineages are Caspase-7-cleavedD198, p70-S6K_pT389, and p90 RSK_pT359_S363. Each is linked with TNS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TNS2-to-partner and partner-to-TNS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TNS2-low versus TNS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNS2→partner) and Y-score (partner→TNS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.750	+1.945	<.001	.002	3	4
SKCM	p70-S6K_pT389 →	+0.160	+1.700	.021	.043	3	2
COAD	p90 RSK_pT359_S363 →	+0.285	+2.815	.003	.036	3	2
UCEC	MSH6 →	-0.406	-1.999	<.001	.008	3	2
UCEC	p62 Lck ligand →	+0.212	+1.584	.029	.002	3	2
UCEC	PRDX1 →	+0.153	+1.652	.013	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Caspase-7-cleavedD198 by TNS2 expression — UCEC

Explore this box plot interactively →