TNS2

Across TCGA pan-cancer cohorts, TNS2 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of TNS2’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where TNS2 RNA is repressed in tumor relative to normal tissue. In most cancer types TNS2 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LUAD, and COAD are the cancer types where TNS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−3.152	<.001	11	view →
LUAD	Male	All	−1.721	<.001	9	view →
COAD	Female	II,III,IV	−0.795	<.001	9	view →
THCA	Male	II,III,IV	−0.667	<.001	9	view →
LUSC	Female	II,III,IV	−2.357	<.001	8	view →
KIRP	Male	All	−1.360	<.001	7	view →
UCEC	All	III,IV	−2.846	<.001	6	view →
BRCA	All	II,III,IV	−1.660	<.001	6	view →
KIRC	All	All	+0.334	.002	5	view →
KICH	All	All	−0.645	<.001	4	view →
STAD	Female	All	−1.378	.006	3	view →
HNSC	Male	All	−0.648	.021	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

TNS2–BLCA

Open the BLCA breakdown →