TNS2

Across TCGA cell cohorts, TNS2 mutation is significantly associated with the RNA expression of many other genes, with 2,092 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNS2-associated genes across cancer lineages are GUCA2A, POLDIP3, and TNRC6B. Each is linked with TNS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNS2-to-partner and partner-to-TNS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by TNS2-low versus TNS2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNS2→partner) and Y-score (partner→TNS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GUCA2A →	+0.052	+3.688	.001	.002	3	2
LARGE_INTESTINE	POLDIP3 →	+0.533	+2.949	.001	<.001	3	2
LARGE_INTESTINE	TNRC6B →	+0.953	+2.949	<.001	<.001	3	2
LARGE_INTESTINE	ZC3H14 →	+0.477	+2.265	.001	.001	3	2
LARGE_INTESTINE	METTL4 →	+0.547	+2.265	.001	.001	3	2
BLOOD_Leukemia	SP4 →	+0.749	+3.351	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,092 associations by consensus.

GUCA2A by TNS2 expression — SKIN

Explore this box plot interactively →