TNS1

Across TCGA cell cohorts, TNS1 mutation is significantly associated with the RNA expression of many other genes, with 493 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNS1-associated genes across cancer lineages are CCDC105, R3HCC1, and PYURF. Each is linked with TNS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNS1-to-partner and partner-to-TNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC105 grouped by TNS1-low versus TNS1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNS1→partner) and Y-score (partner→TNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CCDC105 →	+0.008	+4.029	<.001	.007	3	2
LARGE_INTESTINE	R3HCC1 →	+0.578	+1.949	.006	.002	3	2
LUNG_NSCLC_LUAD	PYURF →	+0.480	+2.621	.001	.003	3	2
LARGE_INTESTINE	ZNF689 →	+0.395	+1.949	.003	.002	3	2
LARGE_INTESTINE	FAM171A2 →	+0.694	+2.523	.001	.003	3	2
LARGE_INTESTINE	GMEB1 →	+0.485	+1.949	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 493 associations by consensus.

CCDC105 by TNS1 expression — PANCREAS

Explore this box plot interactively →