TNRC6C

Across TCGA cell cohorts, TNRC6C mutation is significantly associated with the RNA expression of many other genes, with 396 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNRC6C-associated genes across cancer lineages are KRTAP5-4, TSPAN31, and FAM205A. Each is linked with TNRC6C in more than 1 cancer types. Because this analysis shows association rather than direction, both TNRC6C-to-partner and partner-to-TNRC6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-4 grouped by TNRC6C-low versus TNRC6C-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNRC6C→partner) and Y-score (partner→TNRC6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP5-4 →	+0.028	+5.369	<.001	.004	3	2
CNS	TSPAN31 →	-1.067	-3.321	<.001	.003	3	2
OVARY	FAM205A →	+0.037	+2.866	.001	.008	3	2
SKIN	HINT1 →	+0.485	+3.299	.003	.004	3	2
LARGE_INTESTINE	GCAT →	+0.909	+2.459	.009	.006	3	2
LARGE_INTESTINE	GPR63 →	+0.809	+2.265	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 396 associations by consensus.

KRTAP5-4 by TNRC6C expression — SOFT_TISSUE

Explore this box plot interactively →