TNRC6B

Across TCGA patient cohorts, TNRC6B mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNRC6B-associated genes across cancer lineages are Caspase-7-cleavedD198, GAPDH, and ATM. Each is linked with TNRC6B in more than 4 cancer types. Because this analysis shows association rather than direction, both TNRC6B-to-partner and partner-to-TNRC6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TNRC6B-low versus TNRC6B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNRC6B→partner) and Y-score (partner→TNRC6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.892	+2.330	<.001	<.001	3	5
SKCM	GAPDH →	+0.540	+3.321	.033	.009	3	3
UCEC	ATM →	-0.494	-1.459	<.001	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.131	-0.986	.001	.007	3	3
UCEC	MEK1 →	+0.346	+1.716	<.001	<.001	3	3
BLCA	PAI-1 →	+0.688	+2.824	.032	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Caspase-7-cleavedD198 by TNRC6B expression — COAD

Explore this box plot interactively →