TNRC6B

Across TCGA cell cohorts, TNRC6B mutation is significantly associated with the RNA expression of many other genes, with 1,924 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNRC6B-associated genes across cancer lineages are ASB18, CGB5, and PACS2. Each is linked with TNRC6B in more than 2 cancer types. Because this analysis shows association rather than direction, both TNRC6B-to-partner and partner-to-TNRC6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB18 grouped by TNRC6B-low versus TNRC6B-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNRC6B→partner) and Y-score (partner→TNRC6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ASB18 →	+0.088	+3.954	<.001	.001	3	3
BLOOD_Leukemia	CGB5 →	+0.025	+2.561	.002	.003	3	3
LARGE_INTESTINE	PACS2 →	+0.551	+2.584	.001	.002	3	3
LARGE_INTESTINE	CYB5D1 →	+1.332	+3.949	<.001	<.001	3	3
LARGE_INTESTINE	POMK →	+1.180	+2.850	<.001	<.001	3	3
LARGE_INTESTINE	CSNK1E →	+0.533	+3.321	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,924 associations by consensus.

ASB18 by TNRC6B expression — STOMACH

Explore this box plot interactively →