TNRC6A

Across TCGA patient cohorts, TNRC6A mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNRC6A-associated genes across cancer lineages are Caspase-7-cleavedD198, FASN, and MEK1. Each is linked with TNRC6A in more than 3 cancer types. Because this analysis shows association rather than direction, both TNRC6A-to-partner and partner-to-TNRC6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TNRC6A-low versus TNRC6A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNRC6A→partner) and Y-score (partner→TNRC6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.605	+3.186	<.001	.009	3	4
COAD	FASN →	+0.446	+2.467	.008	.011	3	3
SKCM	MEK1 →	+0.348	+1.807	.017	.026	3	3
SKCM	4E-BP1 →	+0.304	+1.807	.014	.026	3	3
UCEC	eIF4E →	+0.148	+2.150	.005	<.001	3	3
UCEC	GAPDH →	+0.266	+1.415	.048	.040	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Caspase-7-cleavedD198 by TNRC6A expression — COAD

Explore this box plot interactively →