TNRC6A

Across TCGA pan-cancer cohorts, TNRC6A RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TNRC6A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TNRC6A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNRC6A is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where TNRC6A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNRC6A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.911	<.001	11	view →
KIRP	All	IV	+0.797	.007	8	view →
KIRC	All	All	+0.297	<.001	8	view →
THCA	All	All	−0.370	.001	6	view →
UCEC	All	All	−0.717	<.001	4	view →
CHOL	Male	All	+1.214	<.001	3	view →
LIHC	All	All	+0.318	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

TNRC6A–HNSC

Open the HNSC breakdown →