TNRC6A

Across TCGA cell cohorts, TNRC6A mutation is significantly associated with the RNA expression of many other genes, with 1,117 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNRC6A-associated genes across cancer lineages are METTL4, PPM1M, and PRPSAP2. Each is linked with TNRC6A in more than 2 cancer types. Because this analysis shows association rather than direction, both TNRC6A-to-partner and partner-to-TNRC6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL4 grouped by TNRC6A-low versus TNRC6A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNRC6A→partner) and Y-score (partner→TNRC6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	METTL4 →	+0.578	+2.526	<.001	.002	3	3
BLOOD_Leukemia	PPM1M →	+0.961	+3.459	.001	.002	3	3
BLOOD_Leukemia	PRPSAP2 →	+0.672	+2.730	<.001	.001	3	3
BLOOD_Leukemia	FAM169A →	+0.887	+2.730	.002	.001	3	3
CNS	SCO1 →	+0.700	+3.238	.001	.006	3	2
LARGE_INTESTINE	HSCB →	+0.518	+2.364	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,117 associations by consensus.

METTL4 by TNRC6A expression — LARGE_INTESTINE

Explore this box plot interactively →