TNRC18

Across TCGA pan-cancer cohorts, TNRC18 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TNRC18 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TNRC18 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TNRC18 expression acts as an unfavorable survival marker, although some lineages such as BLCA and STAD show a favorable association.

UCEC, HNSC, and LIHC are the cancer types where TNRC18 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.259	0.770	<.001	12	view →
HNSC	OS	Median	IV	0.191	0.739	<.001	12	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	9	view →
BLCA	DFS	Median	All	0.781	0.327	.028	6	view →
PRAD	DFS	Median	All	0.617	0.886	.035	6	view →
STAD	DFS	Median	III,IV	1.000	0.318	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TNRC18–UCEC (OS)

Open the UCEC breakdown →