TNRC18

Across TCGA pan-cancer cohorts, TNRC18 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TNRC18’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TNRC18 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNRC18 is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where TNRC18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNRC18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.273	<.001	11	view →
COAD	Female	All	+0.744	<.001	11	view →
LIHC	Female	II,III,IV	+1.392	<.001	9	view →
STAD	Male	II,III,IV	+1.705	<.001	7	view →
BRCA	All	II,III,IV	+0.398	<.001	6	view →
CHOL	Male	All	+2.403	<.001	5	view →
LUAD	All	III,IV	+0.688	.023	4	view →
PAAD	All	All	+0.629	<.001	4	view →
LUSC	All	All	+0.368	.003	4	view →
ESCA	Female	All	+1.016	.041	2	view →
READ	All	III,IV	+0.969	.002	2	view →
BLCA	All	IV	−0.614	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TNRC18–HNSC

Open the HNSC breakdown →