TNRC18

Across TCGA pan-cancer cohorts, TNRC18 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TNRC18 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TNRC18 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TNRC18 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where TNRC18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.749	0.977	.001	85	view →
UCEC	OS	Median	II,III,IV	0.638	1.000	.014	4	view →
LUAD	DFS	Median	III,IV	0.532	0.896	.018	3	view →
GBM	DFS	Tertile	All	0.795	0.523	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TNRC18–HNSC (OS)

Open the HNSC breakdown →