TNRC18

Across TCGA patient cohorts, TNRC18 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNRC18-associated genes across cancer lineages are Smad4, A-Raf_pS299, and Annexin-1. Each is linked with TNRC18 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNRC18-to-partner and partner-to-TNRC18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad4 grouped by TNRC18-low versus TNRC18-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNRC18→partner) and Y-score (partner→TNRC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Smad4 →	+0.153	+2.906	<.001	.001	3	3
UCEC	A-Raf_pS299 →	-0.115	-1.289	<.001	.021	3	3
UCEC	Annexin-1 →	+0.624	+2.058	<.001	<.001	3	2
LUSC	S6_pS240_S244 →	+0.563	+2.816	.048	.036	3	2
STAD	Ku80 →	+0.292	+3.000	.033	.034	3	2
STAD	Claudin-7 →	+0.609	+2.321	.040	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

Smad4 by TNRC18 expression — COAD

Explore this box plot interactively →