TNRC18

Across TCGA cell cohorts, TNRC18 mutation is significantly associated with the RNA expression of many other genes, with 2,105 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNRC18-associated genes across cancer lineages are SERAC1, TTC21B, and SEMA4F. Each is linked with TNRC18 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNRC18-to-partner and partner-to-TNRC18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERAC1 grouped by TNRC18-low versus TNRC18-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNRC18→partner) and Y-score (partner→TNRC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SERAC1 →	+0.563	+2.730	.004	.001	3	3
BLOOD_Leukemia	TTC21B →	+0.414	+2.730	.009	.001	3	3
BLOOD_Leukemia	SEMA4F →	+0.935	+3.367	<.001	.002	3	3
OVARY	GYS1 →	+0.820	+1.799	.001	.008	3	3
SKIN	RPSA →	+0.471	+2.850	.002	<.001	3	3
LARGE_INTESTINE	HMGXB4 →	+0.702	+2.981	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,105 associations by consensus.

SERAC1 by TNRC18 expression — BLOOD_Leukemia

Explore this box plot interactively →