TNR

Across TCGA patient cohorts, TNR mutation is significantly associated with the RNA expression of many other genes, with 5,225 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TNR-associated genes across cancer lineages are CPE, BRI3BP, and PRC1. Each is linked with TNR in more than 5 cancer types. Because this analysis shows association rather than direction, both TNR-to-partner and partner-to-TNR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPE grouped by TNR-low versus TNR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNR→partner) and Y-score (partner→TNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CPE →	-0.617	-1.062	.001	<.001	3	6
LUAD	BRI3BP →	+0.375	+1.371	<.001	.002	3	5
LUAD	PRC1 →	+0.543	+1.247	<.001	.001	3	5
UCEC	ADAM33 →	-0.589	-2.117	.005	.003	3	5
UCEC	CHAF1A →	+0.490	+2.269	<.001	<.001	3	5
BLCA	SLC25A33 →	+0.525	+3.242	.004	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,225 associations by consensus.

CPE by TNR expression — SKCM

Explore this box plot interactively →