TNR

Across TCGA patient cohorts, TNR mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNR-associated genes across cancer lineages are Cyclin-E2, FoxM1, and TFRC. Each is linked with TNR in more than 5 cancer types. Because this analysis shows association rather than direction, both TNR-to-partner and partner-to-TNR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by TNR-low versus TNR-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNR→partner) and Y-score (partner→TNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Cyclin-E2 →	+0.341	+3.459	<.001	.005	3	6
BLCA	FoxM1 →	+0.278	+2.842	.009	.033	3	4
LUSC	TFRC →	+0.394	+1.362	.018	.027	3	4
UCEC	Cyclin-B1 →	+0.481	+1.584	.004	.002	3	4
COAD	PKC-delta_pS664 →	-0.095	-1.576	.012	.004	3	3
BLCA	Lck →	-0.283	-3.321	.017	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

Cyclin-E2 by TNR expression — BLCA

Explore this box plot interactively →