TNR

Across TCGA cell cohorts, TNR mutation is significantly associated with the RNA expression of many other genes, with 1,925 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNR-associated genes across cancer lineages are OR9A4, SNTG2, and C3orf62. Each is linked with TNR in more than 2 cancer types. Because this analysis shows association rather than direction, both TNR-to-partner and partner-to-TNR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9A4 grouped by TNR-low versus TNR-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNR→partner) and Y-score (partner→TNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR9A4 →	+0.018	+1.570	.001	.008	3	3
STOMACH	SNTG2 →	+0.391	+4.044	.001	.003	3	3
OVARY	C3orf62 →	+0.725	+3.078	<.001	.007	3	3
LARGE_INTESTINE	HDDC2 →	+0.614	+2.364	.001	<.001	3	3
LARGE_INTESTINE	SLFNL1 →	+0.316	+2.339	<.001	.009	3	2
LUNG_NSCLC_LUSC	TSTD3 →	-0.583	-3.063	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,925 associations by consensus.

OR9A4 by TNR expression — SKIN

Explore this box plot interactively →