TNR-IT1

Across TCGA pan-cancer cohorts, TNR-IT1 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated TNR-IT1 data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher TNR-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TNR-IT1 expression acts as an unfavorable survival marker, although some lineages such as PAAD show a favorable association.

ESCA, PAAD, and UCEC are the cancer types where TNR-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Tertile	All	0.198	0.872	.003	36	view →
PAAD	OS	Tertile	II,III,IV	1.000	0.326	.023	24	view →
UCEC	DFS	Tertile	All	0.722	0.847	.014	24	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	18	view →
KIRC	DFS	Tertile	IV	0.293	0.653	.016	18	view →
TGCT	DFS	Tertile	II,III,IV	0.088	0.917	.010	18	view →
LUSC	OS	Tertile	II,III,IV	0.106	0.733	<.001	18	view →
STAD	OS	Tertile	II,III,IV	0.161	0.571	.032	9	view →
CHOL	OS	Tertile	All	0.154	0.793	.004	9	view →
GBM	DFS	Tertile	All	0.131	0.254	.029	9	view →
READ	DFS	Tertile	All	0.162	0.559	.039	9	view →
LIHC	OS	Tertile	All	0.152	0.563	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

TNR-IT1–ESCA (OS)

Open the ESCA breakdown →