TNPO1

Across TCGA patient cohorts, TNPO1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,885 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TNPO1-associated genes across cancer lineages are EMC3-AS1, PTPRB, and LYVE1. Each is linked with TNPO1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TNPO1-to-partner and partner-to-TNPO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TNPO1 versus EMC3-AS1 in LSCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNPO1→partner) and Y-score (partner→TNPO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EMC3-AS1 →	+0.517	+0.213	<.001	<.001	3	6
CCRCC	PTPRB →	-0.835	-0.154	<.001	<.001	3	5
BRCA	LYVE1 →	-1.402	-0.271	<.001	<.001	3	5
LUAD	CCNB1 →	+0.951	+0.147	.001	.004	3	5
UCEC	TROAP →	+0.850	+0.134	.004	<.001	3	5
OV	CENPH →	+0.864	+0.279	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,885 associations by consensus.

TNPO1 vs EMC3-AS1 — LSCC

Explore this scatter interactively →