TNPO1

Across TCGA pan-cancer cohorts, TNPO1 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated TNPO1 data layer compared with 9 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TNPO1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TNPO1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

UVM, LIHC, and HNSC are the cancer types where TNPO1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.244	0.751	<.001	71	view →
LIHC	OS	Median	All	0.606	0.768	<.001	59	view →
HNSC	OS	Tertile	III,IV	0.505	0.820	.001	48	view →
KIRC	DFS	Median	All	0.768	0.481	<.001	47	view →
KICH	DFS	Quartile	II,III,IV	0.438	0.937	.003	40	view →
LGG	OS	Median	All	0.749	0.874	<.001	39	view →
LUAD	OS	Quartile	All	0.561	0.744	<.001	38	view →
CESC	DFS	Tertile	All	0.745	0.879	.001	36	view →
MESO	OS	Tertile	III,IV	0.417	0.684	.007	28	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	27	view →
THCA	OS	Median	II,III,IV	0.837	0.979	.006	26	view →
READ	OS	Tertile	III,IV	0.838	0.339	.010	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

TNPO1–UVM (DFS)

Open the UVM breakdown →