TNPO1

Across TCGA patient cohorts, TNPO1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNPO1-associated genes across cancer lineages are ASNS, mTOR_pS2448, and ATM. Each is linked with TNPO1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TNPO1-to-partner and partner-to-TNPO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TNPO1-low versus TNPO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNPO1→partner) and Y-score (partner→TNPO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.377	+1.514	<.001	.014	3	4
UCEC	mTOR_pS2448 →	-0.088	-1.420	.041	.022	3	3
UCEC	ATM →	-0.539	-2.146	<.001	<.001	3	3
UCEC	INPP4B →	-0.225	-2.169	.016	.002	3	2
UCEC	Notch1 →	+0.121	+1.598	.003	.019	3	2
UCEC	Rab25 →	-0.360	-2.502	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ASNS by TNPO1 expression — UCEC

Explore this box plot interactively →