TNPO1

Across TCGA cell cohorts, TNPO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,267 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNPO1-associated GO terms across cancer lineages are DNA-templated transcription elongation, Negative regulation of cell cycle process, and Protein localization to condensed chromosome. Each is linked with TNPO1 in more than 16 cancer types. Because this analysis shows association rather than direction, both TNPO1-to-partner and partner-to-TNPO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription elongation grouped by TNPO1-low versus TNPO1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNPO1→partner) and Y-score (partner→TNPO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DNA-templated transcription elongation →	+0.111	+1.216	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.065	+1.054	.001	.001	3	16
STOMACH	Protein localization to condensed chromosome →	+0.157	+0.962	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitotic cell cycle →	+0.099	+1.303	<.001	<.001	3	16
BLOOD_Myeloma	Positive regulation of mRNA processing →	+0.148	+1.284	<.001	<.001	3	16
LARGE_INTESTINE	Centrosome duplication →	+0.086	+0.907	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,267 associations by consensus.

DNA-templated transcription elongation by TNPO1 expression — OVARY

Explore this box plot interactively →