TNPO1

Across TCGA cell cohorts, TNPO1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNPO1-associated genes across cancer lineages are RBMY1A1, ZC2HC1B, and PCARE. Each is linked with TNPO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNPO1-to-partner and partner-to-TNPO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1A1 grouped by TNPO1-low versus TNPO1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNPO1→partner) and Y-score (partner→TNPO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	2
BLOOD_Lymphoma	ZC2HC1B →	+0.121	+3.736	.004	.009	3	1
BLOOD_Lymphoma	PCARE →	+0.030	+3.523	<.001	.009	3	1
BLOOD_Lymphoma	OR52B2 →	+0.024	+3.714	<.001	.006	3	1
SKIN	OR56A1 →	+0.019	+4.977	<.001	.007	3	1
SKIN	TEX49 →	+0.045	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

RBMY1A1 by TNPO1 expression — OVARY

Explore this box plot interactively →