TNP2

Across TCGA patient cohorts, TNP2 mutation is significantly associated with the RNA expression of many other genes, with 134 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TNP2-associated genes across cancer lineages are GXYLT1P6, RPS29P22, and SNORD53B. Each is linked with TNP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNP2-to-partner and partner-to-TNP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GXYLT1P6 grouped by TNP2-low versus TNP2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNP2→partner) and Y-score (partner→TNP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GXYLT1P6 →	+0.218	+3.335	<.001	.001	3	2
UCEC	RPS29P22 →	+0.474	+3.382	.002	.004	3	2
UCEC	SNORD53B →	+0.914	+3.572	.005	.006	3	2
SKCM	RN7SKP43 →	+0.265	+3.159	<.001	.008	3	2
SKCM	SLC25A6P4 →	+0.163	+3.708	.004	.002	3	2
SKCM	MIR548O2 →	+0.178	+4.328	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 134 associations by consensus.

GXYLT1P6 by TNP2 expression — SKCM

Explore this box plot interactively →