TNP1

Across TCGA patient cohorts, TNP1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNP1-associated genes across cancer lineages are JNK2, Ku80, and Shc_pY317. Each is linked with TNP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNP1-to-partner and partner-to-TNP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by TNP1-low versus TNP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNP1→partner) and Y-score (partner→TNP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.322	+3.009	.005	.019	3	1
UCEC	Ku80 →	+0.271	+3.013	.047	.019	3	1
UCEC	Shc_pY317 →	-0.224	-3.000	.010	.037	3	1
UCEC	AR →	-0.428	-3.000	.047	.037	3	1
UCEC	beta-Catenin →	+0.711	+3.000	.015	.037	3	1
UCEC	E-Cadherin →	+0.603	+3.000	.032	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

JNK2 by TNP1 expression — UCEC

Explore this box plot interactively →